The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.

This article deals with mechanisms conceived as composed of entities and activities. In response to many perplexities about the nature of activities, a number of arguments are developed concerning their epistemic and ontological status. Some questions concerning the relations between cause and causal explanation and mechanisms are also addressed.

Descartes's works are often treated as a unified, unchanging whole. But in Descartes's Changing Mind, Peter Machamer and J. E. McGuire argue that the philosopher's views, particularly in natural philosophy, actually change radically between his early and later works--and that any interpretation of Descartes must take account of these changes. The first comprehensive study of the most significant of these shifts, this book also provides a new picture of the development of Cartesian science, epistemology, and metaphysics. No changes in Descartes's (...) thought are more significant than those that occur between the major works The World and Principles of Philosophy. Often seen as two versions of the same natural philosophy, these works are in fact profoundly different, containing distinct conceptions of causality and epistemology. Machamer and McGuire trace the implications of these changes and others that follow from them, including Descartes's rejection of the method of abstraction as a means of acquiring knowledge, his insistence on the infinitude of God's power, and his claim that human knowledge is limited to that which enables us to grasp the workings of the world and develop scientific theories. (shrink)

Not only a hero of the scientific revolution, but after his conflict with the church, a hero of science, Galileo is today rivalled in the popular imagination only by Newton and Einstein. But what did Galileo actually do, and what are the sources of the popular image we have of him? This 1998 collection of specially-commissioned essays is unparalleled in the depth of its coverage of all facets of Galileo's work. A particular feature of the volume is the treatment of (...) Galileo's relationship with the church. It will be of interest to philosophers, historians of science, cultural historians and those in religious studies. (shrink)

Some biological processes move from step to step in a way that cannot be completely understood solely in terms of causes and correlations. This paper develops a notion of mechanistic information that can be used to explain the continuities of such processes. We compare them to processes that do not involve information. We compare our conception of mechanistic information to some familiar notions including Crick’s idea of genetic information, Shannon-Weaver information, and Millikan’s biosemantic information.

This paper details the ontological and epistemic character of activties that occur in mechanisms. It explains why they are sufficient to handle the problems of causation.

Descartes is always concerned about knowledge. However, the Galileo affair in 1633, the reactions to his Discourse on method, and later his need to reply to objections to his Meditations provoked crises in Descartes’s intellectual development the import of which has not been sufficiently recognized. These events are the major reasons why Descartes’s philosophical position concerning how we know and what we may know is radically different at the end of his life from what it was when he began. We (...) call this later position Descartes’s epistemic stance and contrast it with his earlier methodological, metaphysical realism. Yet Descartes’s epistemic views cannot be separated from other aspects of his work, for example, his views concerning God, causality, metaphysics, and the nature of science. A further meta-implication is that serious errors await any scholar who cites early Cartesian texts in support of late Cartesian positions, or who uses later texts in conjunction with early ones to support a reading of Descartes’s philosophy.Keywords: René Descartes; Nature; Motion; Method; Knowledge. (shrink)

Surveys theories in contemporary neuroscience, exploring many of its methodological techniques and problems.

We argue that Isaac Newton really is best understood as being in the tradition of the Mechanical Philosophy and, further, that Newton saw himself as being in this tradition. But the tradition as Newton understands it is not that of Robert Boyle and many others, for whom the Mechanical Philosophy was defined by contact action and a corpuscularean theory of matter. Instead, as we argue in this paper, Newton interpreted and extended the Mechanical Philosophy's slogan “matter and motion” in reference (...) to the long and distinguished tradition of mixed mathematics and the study of simple machines. (shrink)

The papers collected here are the result of an INTERNATIONAL SYMPOSIUM: Data · Phenomena · Theories: What’s the notion of a scientific phenomenon good for? held in Heidelberg in September 2008. The event was organized by the research group Causality, Cognition, and the Constitution of Scientific Phenomena in cooperation with Philosophy Department at the University of Heidelberg (Peter McLaughlin and Andreas Kemmerling) and the IWH Heidelberg. The symposium was supported by the Emmy-Noether-Programm der Deutschen Forschungsgemeinschaft and by Stiftung Universitat Heidelebrg (...) . The workshop was held in honor of Daniela Bailer-Jones, who died on 13 November 2006 at the age of 37 (cf. my 2007 Daniela Bailer-Jones ). Bailer-Jones was an Emmy Noether fellow, and the symposium was arranged and run by those who were working in her research group at the time of her death: Monika Dullstein, Jochen Apel, and Pavel Radchencko. To them goes the credit for the conception, planning, and carrying out of the symposium. (shrink)

The contemporary epistemic status of mental health disciplines does not allow the cross validation of mental disorders among various genetic markers, biochemical pathway or mechanisms, and clinical assessments in neuroscience explanations. We attempt to provide a meta-empirical analysis of the contemporary status of the cross-disciplinary issues existing between neuro-biology and psychopathology. Our case studies take as an established medical mode an example cross validation between biological sciences and clinical cardiology in the case of myocardial infarction. This is then contrasted with (...) the incoherence between neuroscience and psychiatry in the case of bipolar disorders. We examine some methodological problems arising from the neuro-imaging studies, specifically the experimental paradigm introduced by the team of Wayne Drevets. Several theoretical objections are raised: temporal discordance, state independence, and queries about the reliability and specificity, and failure of convergent validity of the inter-disciplinary attempt. Both modern neuroscience and clinical psychology taken as separate fields have failed to reveal the explanatory mechanisms underlying mental disorders. The data acquired inside the mono-disciplinary matrices of neurobiology and psychopathology are deeply insufficient concerning their validity, reliability, and utility. Further, there haven’t been developed any effective trans-disciplinary connections between them. It raises the requirement for development of explanatory significant multi-disciplinary “meta-language” in psychiatry (Berrios, 2006, 2008). We attempt to provide a novel conceptual model for an integrative dialogue between psychiatry and neuroscience that actually includes criteria for cross-validation of the common used psychiatric categories and the different assessment methods. The major goal of our proactive program is the foundation of complementary “bridging” connections of neuroscience and psychopathology which may stabilize the cognitive meta-structure of the mental health knowledge. This entails bringing into synergy the disparate discourses of clinical psychology and neuroscience. One possible model accomplishment of this goal would be the synergistic (or at least compatible) integration of the knowledge under trans-disciplinary convergent cross-validation of the commonly used methods and notions. (shrink)

An overview of how mechanisms work in explanations.

What are the differences between philosophy and science, or between the methods of philosophy and the methods of science? Unlike some philosophers we do not find philosophy and the methods of philosophy to be sui generis. Science, and in particular neuroscience, has much to tell us about the nature of the world and the concepts that we must use to understand and explain it. Yet science cannot function well without reflective analysis of the concepts, methods, and practices that constitute it. (...) For example, experimental methods and their resulting empirical data are essential for understanding the world, yet such data is not a-conceptual. Understanding how and what theoretical assumptions, conceptual assumptions, and practical knowledge guide the use of experimental methods is relevant to understanding the results of that use. In this way, philosophy – whether done by philosophers or scientists – has a role to play in understanding the world. Neuroscience is typically individualistic in focus; nonetheless, the mechanisms of learning and linguistic ability that some neuroscientists study also have a role to play in understanding communication. Philosophy cannot offer adequate understanding, even conceptual clarity, in isolation from empirical investigation. Yet, this does not require that science or scientific concepts will replace or reduce philosophical concepts, let alone those of ordinary language. (shrink)

Titles and abstracts for the Pitt-London Workshop in the Philosophy of Biology and Neuroscience: September 2001.

Leading scholars in the fields of philosophy and the sciences of the mind have contributed to this newest volume in the prestigious Pittsburgh-Konstanz series. Among the problem areas discussed are folk psychology, meanings as conceptual structures, functional and qualitative properties of colors, the role of conscious mental states, representation and mental content, the impact of connectionism on the philosophy of the mind, and supervenience, emergence, and realization. Most of the essays are followed by commentaries that reflect ongoing debates in the (...) philosophy of the mind and often develop a counterpoint to the claims of the essayists. (shrink)

This chapter contains sections titled: Logical Positivism to Logical Empiricism: 1918‐55 New Paradigms and Scientific Change: Late 1950s through the 1970s Contemporary Foci and Future Directions.

The act of interpretation occurs in nearly every area of the arts and sciences. That ubiquity serves as the inspiration for the fourteen essays of this volume, covering many of the domains in which interpretive practices are found. Individual topics include: the general nature of interpretation and its forms; comparing and contrasting interpretation and hermeneutics; culture as interpretation seen through Hegel’s aesthetics; interpreting philosophical texts; methodologies for interpreting human action; interpretation in medical practice focusing on manifestations as indicators of disease; (...) the brain and its interpretative, structured, learning and storage processes; interpreting hybrid wines and cognitive preconceptions of novel objects; and the importance of sensory perception as means of interpreting in the case of dry German Rieslings. In an interesting turn, Nicholas Rescher writes on the interpretation of philosophical texts. Then Catherine Wilson and Andreas Blank explicate and critique Rescher’s theories through analysis of the mill passage from Leibniz’s _Monadology._. (shrink)

Perhaps, the best way to approach a book with as broad a scope and as great an ambition as Philip Kitcher’s The Advancement of Science is to think about its main goal. What vision is it trying to convey? Is it a worthy vision? Later one can ask how well it was done.

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, re-distribution, re-selling, loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden.

Imre Lakatos’ idea that history of science without philosophy of science is blind may still be given a plausible interpretation today, even though his theory of the methodology of scientific research programmes has been rejected. The latter theory captures neither rationality in science nor the sense in which history must be told in a rational fashion. Nonetheless, Lakatos was right in insisting that the discipline of history consists of written rational reconstructions. In this paper, we will examine possible ways to (...) cash out different, philosophically interesting, relationships: between rationality and science, between rationality and philosophy of science and/or epistemology, and, of course, between history and philosophy of science. Our conclusion is that the historian of science may be a philosopher of science as weIl, but if that philosophy of science is essentially a historical and dogmatic, it either cannot be used for history or it will deprive history of some of its most interesting and useful categories. (shrink)